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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

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A Millimeter-scale Single Charged Particle Dosimeter for Cancer Radiotherapy.

Kyoungtae Lee¹, Jessica Scholey², Eric B Norman³

¹Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720 USA.

IEEE Journal of Solid-State Circuits

|December 7, 2020

Summary

This study introduces a novel millimeter-scale CMOS detector for single charged particle detection, crucial for cancer radiotherapy. It enables precise in-vivo dosimetry, marking a significant advancement in radiation monitoring.

Keywords:

CMOS dosimeter In-vivo dosimetry proton beam therapy pulse width sensing single particle detection

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Published on: May 9, 2014

Area of Science:

Medical Physics
Semiconductor Devices
Radiation Detection

Background:

External beam cancer radiotherapy requires precise radiation monitoring for effective treatment.
Current dosimetry methods face challenges in real-time, in-vivo measurements.
Millimeter-scale, high-resolution radiation detectors are needed for advanced applications.

Purpose of the Study:

To develop and demonstrate a CMOS-based system for single charged particle detection.
To enable implantable in-vivo dosimetry for cancer radiotherapy.
To create a power-efficient and compact radiation detection system.

Main Methods:

Designed a 64x64 pixel CMOS detector with 1x1 μm² diodes for energy deposition measurement.
Implemented a pulse width measurement technique to avoid analog-to-digital converters.
Fabricated a prototype Application-Specific Integrated Circuit (ASIC) using TSMC 65 nm LP CMOS process.

Main Results:

Achieved millimeter-scale detection area (512x512 μm²) for charged particles.
Demonstrated successful functionality verification in a 67.5 MeV proton beam.
The prototype ASIC exhibited low average static power consumption (0.535 mW at 1.2 V).

Conclusions:

This work presents the first demonstration of single charged particle detection for implantable in-vivo dosimetry.
The developed system offers a power-efficient and compact solution for radiotherapy monitoring.
The technology holds promise for improving the precision and safety of cancer treatments.