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HER2/neu DNA vaccination for breast tumors
Arianna Smorlesi1, Francesca Papalini, Sara Pierpaoli
1Immunology Center, INRCA Research Department, Ancona, Italy.
Abstract:
Several studies of DNA vaccination against HER2/neu showed the effectiveness of immunization protocols in models of transplantable or spontaneous tumors. The DNA delivery system plays a crucial role in the success of DNA vaccination. In particular, our studies of DNA vaccination against HER2/neu tumor antigen showed that intramuscular injection of the vaccine followed by electroporation elicits an optimal protection against the development of spontaneous HER2/neu- tumors occurring in transgenic mice.
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