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Acneiform eruption induced by lithium carbonate.

¹Department of Dermatology, Nagoya City University Medical School, Japan.

The Journal of Dermatology

|August 1, 1991

Summary

Lithium carbonate, used for psychosis, can cause a severe acne-like rash. This drug-induced folliculitis resolved after discontinuing lithium, indicating a direct link.

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Area of Science:

Dermatology
Psychiatry
Pharmacology

Background:

Lithium carbonate is a common mood stabilizer prescribed for psychiatric disorders.
Acneiform eruptions are a potential side effect of various medications.
Distinguishing drug-induced folliculitis from acne vulgaris is crucial for appropriate management.

Observation:

A 26-year-old female presented with a severe facial, chest, and back eruption shortly after initiating lithium carbonate therapy for psychosis.
The eruption was histopathologically confirmed as folliculitis, not acne vulgaris.
The condition persisted for six months despite initial presentation.

Findings:

Discontinuation of lithium carbonate led to the complete resolution of the folliculitis.
The eruption did not recur in the three years following drug cessation.
This case highlights a direct causal relationship between lithium carbonate and the development of folliculitis.

Implications:

Clinicians should consider lithium carbonate as a potential cause of acneiform eruptions in patients.
Prompt recognition and drug withdrawal can effectively manage lithium-induced folliculitis.
Further research may elucidate the specific mechanisms underlying lithium's dermatological side effects.

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