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Updated: Jul 6, 2026

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
11:28

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically

Published on: September 9, 2015

Dalbavancin.

Vanessa R Anderson1, Gillian M Keating

  • 1Wolters Kluwer Health, Adis, Auckland, New Zealand. demail@adis.co.nz

Drugs
|March 29, 2008
PubMed
Summary
This summary is machine-generated.

Dalbavancin, a potent antibacterial, demonstrated high clinical success rates in treating complicated skin infections. This two-dose intravenous regimen proved effective and well-tolerated in adult patients.

Related Experiment Videos

Last Updated: Jul 6, 2026

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
11:28

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically

Published on: September 9, 2015

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Dermatology

Background:

  • Dalbavancin is a semisynthetic glycopeptide antibacterial agent.
  • It targets Gram-positive bacteria responsible for complicated skin and skin structure infections (cSSSIs).
  • Dalbavancin is administered via a unique two-dose, once-weekly intravenous regimen.

Purpose of the Study:

  • To evaluate the efficacy and safety of dalbavancin in adult patients with cSSSIs.
  • To compare dalbavancin's effectiveness against established treatments.

Main Methods:

  • Two randomized controlled trials were conducted in adult patients with cSSSIs.
  • Efficacy was assessed by clinical success rates at test-of-cure or follow-up visits.
  • Phase III trial: Dalbavancin vs. linezolid (double-blind, multinational).
  • Phase II trial: Dalbavancin vs. comparator antibacterials (open-label, multicentre).

Main Results:

  • Dalbavancin achieved high clinical success rates in both trials (88.9%-94%).
  • In the Phase III trial, dalbavancin was noninferior to linezolid.
  • The comparator group in the Phase II trial showed lower success rates (76%).
  • Dalbavancin was generally well-tolerated, with mild to moderate adverse events.

Conclusions:

  • Dalbavancin is an effective and well-tolerated treatment option for adult cSSSIs.
  • Its two-dose, once-weekly regimen offers a convenient administration schedule.
  • Dalbavancin represents a valuable therapeutic advance for Gram-positive bacterial skin infections.