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Effect of experimental diabetes on craniofacial growth in rats
Mona Aly Abbassy1, Ippei Watari, Kunimichi Soma
1Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo 113-8549, Japan. monaabbassy@gmail.com
Objectives:
The goal of this study was to assess the effect of type 1 diabetes mellitus (T1DM) on the craniofacial growth and skeletal maturation using the STZ-DM rat model.
Design:
Experimental T1DM was induced in 3-week-old male Wistar rats by a single dose of 60 mg/kg body weight of streptozotocin (STZ). Lateral and dorsoventral X-rays of the head were taken at the age of 7 weeks. The X-rays were scanned, digitised and selected linear distances were measured and analysed statistically.
Results:
In STZ-DM statistical analysis of results revealed a reduction in growth of most of the linear measurements in the neurocranium and mandible by X-ray analysis, and all measurements were significantly lower in viscerocranium.
Conclusions:
Uncontrolled T1DM reduces craniofacial growth, resulting in retardation of skeletal development.
