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Carcinogenesis and aging 20 years after: escaping horizon
1Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, Pesochny-2, St. Petersburg 197758, Russia. aging@mail.ru
Mechanisms of Ageing and Development
|March 29, 2008
Summary
Carcinogenesis is a multistage process influenced by external agents and internal factors. Aging significantly impacts cancer development by altering tissue susceptibility and internal homeostasis, affecting tumor progression.
Area of Science:
- Oncology
- Cell Biology
- Gerontology
Background:
- Carcinogenesis is a complex, multistage process involving sequential cellular changes.
- Tissue homeostasis, and nervous, hormonal, and metabolic factors influence cancer development and antitumor resistance.
Purpose of the Study:
- To explore the multistage nature of carcinogenesis.
- To investigate the role of the microenvironment and aging in cancer development.
Main Methods:
- Review of existing literature on carcinogenesis.
- Analysis of factors influencing cancer initiation, promotion, and progression.
Main Results:
- Carcinogenesis involves distinct stages, with transitions affected by various agents.
- Microenvironmental changes can influence cancer progression, duration, and even reverse the process.
- Aging impacts susceptibility to carcinogenesis and facilitates tumor promotion and progression through altered homeostasis.
Conclusions:
- The microenvironment plays a critical role in modulating carcinogenic events and the tumor latent period.
- Aging is a significant risk factor for cancer, predisposing individuals through cellular accumulation and altered immune and endocrine functions.
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