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Comparative analysis of the skeletal changes in tetrapods after brief influence of microgravity

V B Nikitin1, V I Gulimova, E A Ilyin

  • 1Institute of Human Morphology, ul. Tsurupi-3, Moscow, Russia.

Journal of Gravitational Physiology : a Journal of the International Society for Gravitational Physiology
|April 1, 2008
PubMed

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...