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Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Solubility03:00

Solubility

Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...
Colloids03:22

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
Physical Properties of Ethers02:17

Physical Properties of Ethers

Overview
An ether molecule has a net dipole moment due to the polarity of C–O bonds. Subsequently, boiling points of ethers are lower than those of alcohols of comparable molecular weight and slightly higher than those of hydrocarbons of comparable molecular weight (Table 1).
Ethers can act as hydrogen bond acceptors, making them more water-soluble than hydrocarbons, but since ethers cannot act as hydrogen bond donors, they are much less soluble in water than alcohols. Ethers are considered...
Entropy and Solvation02:05

Entropy and Solvation

The process of surrounding a solute with solvent is called solvation. It involves evenly distributing the solute within the solvent. The rule of thumb for determining a solvent for a given compound is that like dissolves like. A good solvent has molecular characteristics similar to those of the compound to be dissolved. For example, polar solutions dissolve polar solutes, and apolar solvents dissolve apolar solutes. A polar solvent is a solvent that has a high dielectric constant (ϵ ≥ 15); an...

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Related Experiment Video

Updated: Jul 6, 2026

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
08:58

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Published on: March 11, 2017

Hemozoin: oil versus water.

John M Pisciotta1, David Sullivan

  • 1The Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe St., Baltimore, MD 21205, USA.

Parasitology International
|April 1, 2008
PubMed
Summary

Quinolines inhibit malaria parasite hemozoin formation. New evidence suggests heme crystallization occurs within lipids, offering novel drug targeting strategies and impacting immune function.

Area of Science:

  • Parasitology
  • Biochemistry
  • Drug Discovery

Background:

  • Quinolines are known to inhibit heme crystallization in malaria parasites.
  • Hemozoin formation and inhibition mechanisms are extensively studied.
  • Recent research explores alternative sites for heme crystallization.

Purpose of the Study:

  • To review evidence for heme crystallization within lipids in various parasites.
  • To discuss the implications of a lipid crystallization site for drug targeting.
  • To explore the role of hemozoin in leukocytes and its effects on erythrocytes.

Main Methods:

  • Literature review of recent evidence on heme crystallization.
  • Analysis of implications for antiparasitic drug development.
  • Examination of hemozoin's role in host-pathogen interactions.

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Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
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Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

Published on: May 25, 2017

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Published on: March 11, 2017

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
10:45

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

Published on: May 25, 2017

Main Results:

  • Evidence supports heme crystallization occurring within lipids in diverse parasites.
  • Lipid-based crystallization presents new opportunities for antimalarial drug targeting.
  • Hemozoin within leukocytes can produce toxic lipid metabolites.

Conclusions:

  • A lipid site of heme crystallization has significant implications for antimalarial drug discovery.
  • Understanding this pathway may lead to novel therapeutic strategies.
  • Further research is needed to elucidate the full impact on host immunity and red blood cell function.