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Gastric schwannomas: radiological features with endoscopic and pathological correlation
1Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seodaemoon-gu, Seoul, Korea.
Clinical Radiology
|April 1, 2008
Summary
Gastric schwannomas are submucosal stomach tumors. Imaging and pathology show well-demarcated, homogeneous masses, with S-100 protein positivity confirming diagnosis.
Area of Science:
- Gastroenterology
- Surgical Pathology
- Radiology
Background:
- Schwannomas are rare tumors arising from Schwann cells, typically found in soft tissues.
- Gastric schwannomas are an uncommon subtype, requiring detailed characterization for accurate diagnosis.
Purpose of the Study:
- To delineate the radiological, endoscopic, and pathological features of gastric schwannomas.
- To correlate imaging findings with histopathological and immunohistochemical results in a cohort of 16 patients.
Main Methods:
- Retrospective review of 16 surgically confirmed gastric schwannoma cases.
- Analysis of computed tomography (CT), upper gastrointestinal series, endoscopy, and endoscopic ultrasonography findings.
- Histopathological examination and immunohistochemistry (c-kit, CD34, smooth muscle actin, S-100 protein) of all specimens.
Main Results:
- Radiologically, gastric schwannomas presented as well-demarcated, homogeneous submucosal masses on CT, with infrequent ulceration.
- Endoscopic evaluation revealed homogeneous submucosal masses contiguous with the muscularis propria.
- Pathological examination showed well-circumscribed, homogeneous tumors composed of spindle cells, with universal S-100 protein positivity.
Conclusions:
- Gastric schwannomas are characterized by submucosal location and well-defined, homogeneous imaging features.
- Endoscopic ultrasonography and gross pathology align with these findings.
- Immunohistochemistry, particularly S-100 protein positivity, is crucial for definitive diagnosis.