[Hypophysectomy as a possible therapy in prostatic carcinoma]

Hypophysectomy had been introduced in the therapy of advanced stages of prostatic carcinoma at the Clinic of Urology, University Hospital in Olomouc, in collaboration with the Research Institute of Higher Nervous Activity, 10 years ago. The tissue of the hypophysis is disintegrated thermodynamically which was performed in 19 patients. At the time of indication for this intervention, three patients had tumor in the stage T3, others in the stage T4. Metastatic spread to regional lymph nodes and skeleton was encountered in all cases. In 2 patients the grade of tumor activity was G2, in others G3. The intervention was indicated due to patient's permanent pains resistant to pharmacological alleviation. The life-span after intervention was 1 month up to 4 years. Remission was recorded in 70% of patients. Changes in serum levels of some hormones after various types of hormone therapy and hypophysectomy are compared.