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[Hypophysectomy as a possible therapy in prostatic carcinoma].

J Scheinar1, K Výborný

  • 1Urologische Klinik, medizinischen Fakultät, Palacký-Universität in Olomouc, Tschechoslowakei.

Acta Universitatis Palackianae Olomucensis Facultatis Medicae
|January 1, 1991
PubMed
Summary

Thermodynamic hypophysectomy offers a palliative option for advanced prostate cancer, achieving remission in 70% of patients with intractable pain. This study explores its efficacy and hormonal changes in advanced prostatic carcinoma therapy.

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Area of Science:

  • Urology
  • Oncology
  • Endocrinology

Context:

  • Advanced prostatic carcinoma presents significant therapeutic challenges, particularly concerning pain management.
  • Hypophysectomy, a surgical procedure involving the removal of the pituitary gland, has been explored as a treatment modality.

Purpose:

  • To evaluate the efficacy of thermodynamically disintegrated hypophysectomy in managing advanced prostate cancer.
  • To assess the impact of hypophysectomy on patient survival and pain relief.
  • To compare hormonal changes following hypophysectomy with other hormone therapies.

Summary:

  • This study involved 19 patients with advanced prostate cancer (T3/T4 stages) and metastatic spread, who underwent thermodynamically disintegrated hypophysectomy for intractable pain.
  • The intervention resulted in a life-span of 1 month to 4 years post-procedure.

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  • A 70% remission rate was observed, indicating significant palliative benefit.

    • Impact:

    • Hypophysectomy demonstrates potential as an effective treatment for advanced prostate cancer, improving quality of life by alleviating pain.
    • The findings contribute to understanding the role of hormonal manipulation in advanced cancer care.
    • Further research can explore optimizing hypophysectomy techniques and patient selection for enhanced outcomes.