Related Experiment Video
Updated: Jul 6, 2026

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination
Published on: April 29, 2015
Targeting intracellular signaling: a novel approach to vaccination
Jeremy Wales1, Brian Foxwell, Marc Feldmann
1Imperial College London, Kennedy Institute of Rheumatology, The Charing Cross Hospital Campus, Arthritis Research Campaign Building, 1 Aspenlea Road, London W6 8LH, UK. j.wales@imperial.ac.uk
Abstract:
Vaccination is well known to control many current infectious diseases. However, the development of cellular (Th1) immunity to control viral pathogens, among others, requires the development of new vaccine adjuvants. The use of Toll-like receptor ligands or cytokines has shown much promise, although specificity and toxicity are issues with these strategies. Targeting intracellular signaling pathways may allow for greater specificity of the adjuvant, as well as reducing systemic toxicity. Studies targeting these pathways are discussed, as well as their potential applications in the future.
Related Concept Videos
Tumor Immunotherapy
Intracellular Signaling Cascades
Intracellular Signaling Cascades
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Vaccines
Targeted Cancer Therapies
There are several types of targeted therapies against specific...

