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Updated: Jul 6, 2026

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
Published on: July 11, 2025
Chance and necessity in chromosomal gene distributions
Rutger Hermsen1, Pieter Rein ten Wolde, Sarah Teichmann
1FOM Institute for Atomic and Molecular Physics, 1098 SJ, Amsterdam, The Netherlands. hermsen@amolf.nl
Abstract:
By analyzing the spacing of genes on chromosomes, we find that transcriptional and RNA-processing regulatory sequences outside coding regions leave footprints on the distribution of intergenic distances. Using analogies between genes on chromosomes and one-dimensional gases, we constructed a statistical null model. We used this to estimate typical upstream and downstream regulatory sequence sizes in various species. Deviations from this model reveal bi-directional transcriptional regulatory regions in Saccharomyces cerevisiae and bi-directional terminators in Escherichia coli.
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