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Related Concept Videos

Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

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A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
02:49

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Published on: February 23, 2024

Cardiac dysfunction after burns.

Z Bak1, F Sjöberg, O Eriksson

  • 1Department of Anesthesia and Intensive Care, Linköping University Hospital, Sweden. zoltan.bak@lio.se

Burns : Journal of the International Society for Burn Injuries
|April 2, 2008
PubMed
Summary
This summary is machine-generated.

Acute myocardial damage is common in severe burn patients during fluid resuscitation, correlating with wall motion abnormalities and troponin leakage. Echocardiography and troponin levels closely track this cardiac injury, even with preserved systolic function.

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Area of Science:

  • Cardiology
  • Intensive Care Medicine
  • Burn Trauma Research

Background:

  • Severe burns (≥20% TBSA) necessitate aggressive fluid resuscitation.
  • Myocardial damage can occur in critically ill burn patients.
  • Early detection of cardiac dysfunction is crucial for patient outcomes.

Purpose of the Study:

  • To investigate the occurrence of cardiac abnormalities during fluid resuscitation in severe burn patients.
  • To assess the association between regional wall motion abnormalities (WMA), diastolic dysfunction, and elevated troponin levels.
  • To correlate echocardiographic findings with myocyte damage markers.

Main Methods:

  • Transesophageal echocardiography (TEE) and simultaneous troponin measurements were performed in 10 severe burn patients (mean Baux index 92.7).
  • Examinations were conducted at 12, 24, and 36 hours post-burn, following Parkland formula resuscitation.
  • Analysis focused on regional WMA, diastolic function, and troponin concentrations.

Main Results:

  • 50% of patients exhibited varying degrees of troponin leakage correlating with WMA at all time points (p<0.05).
  • No discordance was observed between WMA and troponin levels.
  • Shortened mitral deceleration time and increased left ventricular filling velocity and stroke volume were noted.

Conclusions:

  • Acute myocardial damage, evidenced by echocardiography and troponin, is prevalent in severe burn patients undergoing resuscitation.
  • A strong correlation exists between echocardiographic findings and troponin levels, irrespective of global systolic function.
  • Doppler patterns suggest restrictive left ventricular diastolic function in this patient cohort.