Related Experiment Video
Updated: Jul 6, 2026

09:51
The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
Published on: September 7, 2022
Obesity in total hip replacement.
J G Andrew1, J Palan, H V Kurup
11Department of Orthopaedics Ysbyty Gwynedd, Bangor LL57 2PW, UK.
The Journal of Bone and Joint Surgery. British Volume
|April 2, 2008
Summary
Obesity does not negatively impact total hip replacement outcomes. Obese and morbidly obese patients experience similar clinical results and complication rates compared to non-obese individuals after hip surgery.
Area of Science:
- Orthopedic Surgery
- Biomedical Engineering
- Clinical Outcomes Research
Background:
- Obesity is a growing public health concern.
- The impact of obesity on total hip replacement (THR) outcomes remains a subject of investigation.
- Understanding these effects is crucial for patient selection and surgical planning.
Purpose of the Study:
- To investigate the influence of obesity on clinical and radiological outcomes following total hip replacement.
- To compare outcomes across non-obese, obese, and morbidly obese patient groups.
Main Methods:
- Prospective, multi-centre study of 1421 total hip replacements (THRs).
- Patients categorized by body mass index (BMI): non-obese (<30 kg/m²), obese (30-40 kg/m²), and morbidly obese (>40 kg/m²).
- Primary outcome: change in Oxford hip score at 5 years. Secondary outcomes: complication rates (dislocation, infection, DVT, PE), operating time, hospital stay, and radiological changes.
Main Results:
- No significant differences in Oxford hip score changes, complication rates, or radiological outcomes at 5 years between BMI groups.
- Morbidly obese patients were younger and had longer operating times.
- Data were incomplete for 25.5% of hips.
Conclusions:
- Obesity, including morbid obesity, does not adversely affect the clinical or radiological outcomes of total hip replacement at five years.
- Obese and morbidly obese patients derive comparable benefits from THR as non-obese patients.
- While operating times may be longer in the morbidly obese, the overall benefits of THR are similar across BMI categories.
Related Concept Videos
Drug Dosing: Obese Patients
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Obesity
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
