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Related Concept Videos

Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

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Related Experiment Video

Updated: Jul 6, 2026

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
09:51

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

Obesity in total hip replacement.

J G Andrew1, J Palan, H V Kurup

  • 11Department of Orthopaedics Ysbyty Gwynedd, Bangor LL57 2PW, UK.

The Journal of Bone and Joint Surgery. British Volume
|April 2, 2008
PubMed
Summary
This summary is machine-generated.

Obesity does not negatively impact total hip replacement outcomes. Obese and morbidly obese patients experience similar clinical results and complication rates compared to non-obese individuals after hip surgery.

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In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
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Last Updated: Jul 6, 2026

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
09:51

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Published on: September 7, 2022

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

Area of Science:

  • Orthopedic Surgery
  • Biomedical Engineering
  • Clinical Outcomes Research

Background:

  • Obesity is a growing public health concern.
  • The impact of obesity on total hip replacement (THR) outcomes remains a subject of investigation.
  • Understanding these effects is crucial for patient selection and surgical planning.

Purpose of the Study:

  • To investigate the influence of obesity on clinical and radiological outcomes following total hip replacement.
  • To compare outcomes across non-obese, obese, and morbidly obese patient groups.

Main Methods:

  • Prospective, multi-centre study of 1421 total hip replacements (THRs).
  • Patients categorized by body mass index (BMI): non-obese (<30 kg/m²), obese (30-40 kg/m²), and morbidly obese (>40 kg/m²).
  • Primary outcome: change in Oxford hip score at 5 years. Secondary outcomes: complication rates (dislocation, infection, DVT, PE), operating time, hospital stay, and radiological changes.

Main Results:

  • No significant differences in Oxford hip score changes, complication rates, or radiological outcomes at 5 years between BMI groups.
  • Morbidly obese patients were younger and had longer operating times.
  • Data were incomplete for 25.5% of hips.

Conclusions:

  • Obesity, including morbid obesity, does not adversely affect the clinical or radiological outcomes of total hip replacement at five years.
  • Obese and morbidly obese patients derive comparable benefits from THR as non-obese patients.
  • While operating times may be longer in the morbidly obese, the overall benefits of THR are similar across BMI categories.