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Updated: Jul 6, 2026

Expansion of Human Peripheral Blood γδ T Cells using Zoledronate
Published on: September 9, 2011
[Cancer immunotherapy using gammadelta T cells ex vivo expanded by bisphosphonate]
1Kyoto University Hospital, Department of Transfusion Medicine and Cell Therapy.
None:
It has become clear that bisphosphonates (BPs) have diverse antitumor effects. BPs mediate their antitumor effects directly by inactivating Ras related proteins. In addition to the direct effects, BPs expand gammadelta T cells, which exhibit major histocompatibility complex-unrestricted lytic activity and inhibit osteoclastogenesis, resulting the indirect antitumor effects. Based on these pre-clinical studies, several clinical trials which focus on the antitumor effects of BPs have already started.
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