Membranous nephropathy long-term follow-up and association with neoplasia

A ten years follow-up has been made on 66 patients with membranous glomerulonephritis. Eighty per cent of them showed nephrotic syndrome, one third elevated diastolic pressure and in 50% of the patients the GFR was reduced. Histopathologic stating and evolution were made as described by Ehrenreich histology with clinic and prognosis. Seven of 76 cases (11%) showed association with neoplasia; different pathogenetic hypothesis could be risen by this observation. The five year survival was 84% and the ten year survival about 50%. Increasing age and the presence of nephrotic syndrome mainly contribute to a poor prognosis.