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Granuloma annulare anterior uveitis
Harsha S Reddy1, Rahul N Khurana, Narsing A Rao
1Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Ocular Immunology and Inflammation
|April 2, 2008
Summary
Granuloma annulare can cause bilateral anterior uveitis, a rare condition diagnosed by skin findings. This case highlights the link between granuloma annulare and uveitis, potentially associated with sarcoidosis.
Area of Science:
- Ophthalmology
- Dermatology
- Rheumatology
Background:
- Granuloma annulare (GA) is a chronic inflammatory skin condition.
- Anterior uveitis involves inflammation of the iris and ciliary body.
- The association between GA and uveitis is infrequently reported.
Observation:
- A 72-year-old woman with known GA presented with acute bilateral granulomatous anterior uveitis.
- Physical examination confirmed characteristic GA skin lesions on her arms.
- Laboratory workup showed a mildly elevated angiotensin-converting enzyme (ACE) level.
Findings:
- The patient's uveitis resolved with topical corticosteroids and cycloplegics.
- This case illustrates granuloma annulare as a potential cause of anterior uveitis.
- Elevated ACE levels may suggest an underlying systemic inflammatory process, possibly sarcoidosis.
Implications:
- Ophthalmologists should consider GA in patients presenting with anterior uveitis, especially those with characteristic skin findings.
- Systemic evaluation may be warranted in such cases to rule out associated conditions like sarcoidosis.
- Early diagnosis and treatment of GA-associated uveitis are crucial to prevent vision loss.
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