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Updated: Jul 6, 2026
Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
Published on: February 10, 2014
Label-free optical biosensing with slot-waveguides
Carlos A Barrios1, María José Bañuls, Victoria González-Pedro
1Instituto de Sistemas Optoelectrónicos y Microtecnología, Universidad Politécnica de madrid, ETSI Telecommunicación, Ciudad Universitaria s/n, Madrid, Spain. cbarrios@die.upm.es
Abstract:
We demonstrate label-free molecule detection by using an integrated biosensor based on a Si(3)N(4)/SiO(2) slot-waveguide microring resonator. Bovine serum albumin (BSA) and anti-BSA molecular binding events on the sensor surface are monitored through the measurement of resonant wavelength shifts with varying biomolecule concentrations. The biosensor exhibited sensitivities of 1.8 and 3.2 nm/(ng/mm(2)) for the detection of anti-BSA and BSA, respectively. The estimated detection limits are 28 and 16 pg/mm(2) for anti-BSA and BSA, respectively, limited by wavelength resolution.
