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Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
Published on: May 24, 2021
Accelerated whole-heart 3D CSPAMM for myocardial motion quantification
Andrea K Rutz1, Salome Ryf, Sven Plein
1Institute for Biomedical Engineering, University and ETH Zurich, Switzerland. rutz@biomed.ee.ethz.ch
Magnetic Resonance in Medicine
|April 3, 2008
Summary
A new fast 3D cardiac imaging method, complementary spatial modulation of magnetization (CSPAMM), enables whole-heart motion assessment. This technique accurately measures myocardial deformation in patients with heart conditions.
Area of Science:
- Cardiovascular Imaging
- Biomedical Engineering
- Medical Physics
Background:
- Myocardial tissue tagging is crucial for assessing cardiac motion.
- Current 3D CSPAMM methods require long acquisition times and are prone to slice misregistration.
Purpose of the Study:
- To develop and validate a fast 3D CSPAMM technique for comprehensive cardiac motion analysis.
- To enable efficient measurement of global heart deformation in a clinical setting.
Main Methods:
- A novel fast 3D CSPAMM acquisition scheme using localized tagging and a hybrid multishot, segmented EPI sequence.
- Acquisition of data in three orthogonal directions within three short breath-holds.
- Tracking myocardial deformation using an enhanced harmonic phase (HARP) technique.
Main Results:
- The method successfully acquired 3D CSPAMM data in healthy volunteers and myocardial infarction patients.
- Circumferential shortening measurements in healthy subjects ranged from 14.1% to 20.1%.
- Patient data showed regional variations in contraction timing, correlating with myocardial scar.
Conclusions:
- The proposed fast 3D CSPAMM technique significantly reduces acquisition time while providing detailed assessment of cardiac mechanics.
- This method is well-tolerated and shows potential for investigating cardiac function in various disease states.
