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Heparin-coated left heart bypass: renal function and hormonal response.
B M Weiss1, L K von Segesser, W Vetter
1Institute of Anesthesiology, University Hospital, Zürich, Switzerland.
The International Journal of Artificial Organs
|December 1, 1991
Summary
Heparin-coated equipment for left heart bypass (LHBP) improved renal function and urine output in dogs. Hormonal responses varied, with standard equipment showing a stronger renin-angiotensin-aldosterone system activation.
Area of Science:
- Cardiovascular Surgery
- Nephrology
- Physiology
Background:
- Partial left heart bypass (LHBP) is used in cardiac procedures.
- The impact of different bypass equipment on renal function and hormonal balance requires investigation.
Purpose of the Study:
- To compare the effects of standard versus heparin-coated equipment during partial left heart bypass (LHBP) on renal function and hormonal responses in dogs.
Main Methods:
- Ten dogs underwent 6-hour partial LHBP using either standard (heparinized) or heparin-coated equipment.
- Renal function (urine output, creatinine clearance, free-water clearance) and plasma levels of renin activity (PRA), aldosterone, vasopressin, and ANP were monitored.
Main Results:
- Heparin-coated LHBP maintained urine output and significantly improved creatinine and free-water clearance compared to standard equipment.
- Hormonal responses (PRA, aldosterone, vasopressin, ANP) showed transient increases in both groups, with some differences in sustained response and vasopressin levels between groups.
Conclusions:
- Heparin-coated equipment enhances renal function during partial LHBP.
- While hormonal responses are generally similar, subtle differences exist, suggesting potential benefits of heparin-coated systems for renal protection.