Related Experiment Video
Updated: Jul 6, 2026
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
Morphological events found at the invading edge of colorectal carcinomas in baboons
Carlos A Rubio1, Edward Dick, Gene B Hubbard
1Department of Pathology, Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, USA. carlos.rubio@ki.se
Background:
Earlier studies at the growing edge of colorectal cancer (CRC) in humans and rats have shown dilated neoplastic glands, some with a thin layer of flattened tumor cells (FTCs), some lacking one or more groups of consecutive lining tumor cells (called glandular pores, GPs).
Materials And Methods:
The characteristics of the neoplastic glands at the invading edge of CRCs were investigated in 39 baboons. A total of 190 neoplastic glands were studied in the 38 cases of glandular-forming adenocarcinomas.
Results:
In the studied neoplastic glands FTCs or GPs were recorded in 44.7% (85 glands). FTCs were found in 9.5% (18 glands) and GPs in 35.3% (67 glands). Only 7.9% or 3 out of the 38 animals showed neoplastic glands with GPs in the bulk of the tumor.
Conclusion:
In similarity to colorectal adenocarcinomas in humans, flattened tumor cells and glandular pores were found at the invading tumor edge of colorectal adenocarcinomas in baboons. A possible mechanism of host invasion is proposed.
Related Concept Videos
01:35Cancer Cell Migration through Invadopodia
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...