Related Experiment Videos
Stress proteins HSP27 and HSP70i predict survival in non-small cell lung carcinoma
Ewa Malusecka1, Stefania Krzyzowska-Gruca, Jacek Gawrychowski
1Department of Tumor Biology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Branch Gliwice, 44-101 Gliwice, Poland. maluseck@io.gliwice.pl
Background:
The expression pattern of stress (heat shock) proteins (HSPs) in cancer cells is frequently different from that observed in normal cells; most often some stress-inducible HSPs are constitutively and highly expressed. The objective of this study was to determine the prognostic significance of stress proteins HSP70i and HSP27 in non-small cell lung carcinoma (NSCLC).
Materials And Methods:
An immunohistochemical procedure that enables unambiguous detection of HSP70i protein was used.
Results:
Strong HSP70i staining showed a survival advantage, although multivariate analysis did not confirm this result. There was an evident correlation between HSP27 overexpression and survival of patients and the results were confirmed by multivariate analysis: 70% of patients with HSP27-negative tumors died within one year after the surgery.
Conclusion:
Our data suggest that HSP27 and HSP70i positivity may represent a favorable prognostic factor in NSCLC.
