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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

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Related Experiment Video

Updated: Jul 6, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Pseudosarcomas of soft tissue.

Andrew E Rosenberg¹

¹Department of Pathology, James Homer Wright Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. arosenberg@partners.org

Archives of Pathology & Laboratory Medicine

|April 4, 2008

Summary

This summary is machine-generated.

Pseudosarcomas are non-cancerous soft tissue lesions that mimic sarcoma due to rapid growth and cellular atypia. Accurate diagnosis of these benign conditions prevents unnecessary aggressive treatment.

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Area of Science:

Soft tissue pathology
Surgical pathology
Oncologic pathology

Background:

Pseudosarcomas are frequently misdiagnosed as malignant sarcomas.
These lesions pose diagnostic challenges due to their concerning histological features.

Purpose of the Study:

To highlight common pseudosarcomatous lesions in soft tissue pathology.
To emphasize the importance of accurate recognition to avoid overtreatment.

Main Methods:

Review of common fibroblastic/myofibroblastic and matrix-forming pseudosarcomas.
Discussion of key diagnostic features differentiating benign from malignant lesions.

Main Results:

Common pseudosarcomas include nodular fasciitis, proliferative fasciitis, myositis ossificans, and others.
These lesions exhibit rapid growth, hypercellularity, atypia, and mitotic activity, mimicking sarcoma.

Conclusions:

Accurate identification of pseudosarcomas is crucial.
Simple excision is typically curative, preventing the need for aggressive therapies.