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A Parent General Behavior Inventory subscale to measure sleep disturbance in pediatric bipolar disorder

Oren I Meyers1, Eric A Youngstrom

  • 1Mandel School of Applied Social Sciences, Case Western Reserve University, Cleveland, Ohio 44106-7123, USA. oren.meyers@case.edu

The Journal of Clinical Psychiatry
|April 4, 2008
PubMed

Insights

Sleep disturbances reliably differentiate children with bipolar spectrum disorders from those with ADHD. A new sleep subscale on the Parent General Behavior Inventory (P-GBI) effectively identifies these sleep problems in youth.

Area of Science:

  • Child and Adolescent Psychiatry
  • Sleep Medicine
  • Behavioral Genetics

Background:

  • Sleep disturbance is a key differentiator between pediatric bipolar spectrum disorders (BSD) and attention-deficit/hyperactivity disorder (ADHD).
  • Investigating sleep-related items as potential endophenotypic markers for BSD is crucial for early identification and intervention.

Purpose of the Study:

  • To evaluate the psychometric properties of a novel sleep subscale derived from the Parent General Behavior Inventory (P-GBI).
  • To determine if this P-GBI sleep subscale can serve as a reliable endophenotypic marker for bipolar spectrum disorders in children.

Main Methods:

  • Utilized data from 625 youths and parents who underwent semistructured interviews (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version).
  • Parents completed the 73-item Parent General Behavior Inventory (P-GBI), from which a sleep subscale was extracted.

Main Results:

  • Youth with bipolar spectrum disorders (BSD) exhibited significantly higher scores on all seven sleep variables compared to other participants (p < .005).
  • Receiver operating characteristic (ROC) analysis showed the P-GBI sleep subscale demonstrated strong discrimination for BSD, comparable to established P-GBI scales (AUC = 0.74).

Conclusions:

  • The P-GBI sleep subscale is a reliable tool for assessing mood-related sleep issues in youth diagnosed with BSD.
  • Sleep disturbance emerges as a promising endophenotype for BSD, with the P-GBI sleep scale offering a cost-effective research measure.
  • Further research should compare parent-reported sleep data with objective measures like actigraphy and polysomnography.
Abstract

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