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NiO Nanoflowers for Non-Enzymatic Amperometric Detection of Glucose
Published on: December 30, 2025
Amperometric glucose biosensor based on single-walled carbon nanohorns
Xiaoqing Liu1, Lihong Shi, Wenxin Niu
1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China.
Biosensors & Bioelectronics
|April 5, 2008
Summary
This study developed a novel amperometric glucose biosensor using single-walled carbon nanohorns (SWCNHs) and glucose oxidase. The SWCNH-based biosensor demonstrates high sensitivity and stability for glucose detection.
Area of Science:
- Nanomaterials Science
- Electrochemistry
- Biotechnology
Background:
- Single-walled carbon nanohorns (SWCNHs) possess unique properties like high surface area and purity.
- SWCNHs show potential for biomolecular immobilization and biosensing applications.
Purpose of the Study:
- To fabricate and characterize an amperometric glucose biosensor utilizing SWCNHs.
- To evaluate the performance of the SWCNH-based glucose biosensor for glucose detection.
Main Methods:
- Fabrication of a glucose biosensor by encapsulating glucose oxidase in a Nafion-SWCNHs composite film.
- Electrochemical characterization using cyclic voltammetry.
- Incorporation of ferrocene monocarboxylic acid as a redox mediator to lower detection potential.
Main Results:
- The immobilized glucose oxidase exhibited well-defined redox peaks at -0.453 V.
- The biosensor displayed good electrocatalytic activity for glucose oxidation.
- The mediated biosensor showed a linear detection range of 0–6.0 mM with high sensitivity (1.06 µA/mM) and stability, while minimizing interference.
Conclusions:
- SWCNHs are a promising material for developing sensitive and stable glucose biosensors.
- The developed biosensor offers advantages in terms of sensitivity, stability, and interference resistance.
- SWCNHs and their composites are well-suited for biomolecular immobilization and advanced biosensing platforms.
