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Human orf and milkers' nodule: a clinicopathologic study
R W Groves1, E Wilson-Jones, D M MacDonald
1Laboratory of Applied Dermatopathology, United Medical School, Guy's Hospital, London, U.K.
Journal of the American Academy of Dermatology
|October 1, 1991
Summary
Orf and milkers' nodule infections, often acquired from farm animals, present distinct clinical and histopathologic features. Viral cytopathic changes, including spongiform vacuolation, are frequently observed in affected skin lesions.
Area of Science:
- Dermatology
- Veterinary Medicine
- Pathology
Background:
- Orf and milkers' nodule are zoonotic viral infections.
- These infections are typically transmitted through direct contact with infected animals.
Purpose of the Study:
- To describe the clinical and histopathologic characteristics of orf and milkers' nodule infections.
- To identify distinctive features that aid in diagnosis.
Main Methods:
- Clinical data collection from 17 patients.
- Histopathologic examination of skin lesions under low and high power microscopy.
Main Results:
- Lesions commonly occurred on hands/arms of males with farm animal contact.
- Histopathology revealed endophytic epidermal proliferations, dermal edema, capillary changes, and inflammation.
- High-power examination showed viral cytopathic effects, including inclusion bodies and spongiform vacuolation.
Conclusions:
- Orf and milkers' nodule infections exhibit unique histopathologic findings.
- Viral cytopathic changes are frequently identifiable, contrary to some prior reports.