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Related Experiment Video

Updated: Jul 6, 2026

Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver

Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver

Published on: June 16, 2023

[Drugs to reduce transfusion needs during surgery].

¹Avdeling for immunologi og transfusjonsmedisin, St. Olavs Hospital, 7006 Trondheim. hilde.pleym@stolav.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke

|April 5, 2008

Summary

Drug therapies can reduce the need for blood transfusions during and after surgery. Tranexamic acid is effective in certain orthopedic and cardiac procedures, while desmopressin shows no benefit in patients with normal hemostasis.

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Last Updated: Jul 6, 2026

Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver

Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver

Published on: June 16, 2023

Area of Science:

Anesthesiology
Hematology
Surgical Medicine

Background:

Blood components are a scarce and costly resource, and transfusions carry significant risks.
Pharmacological interventions can mitigate the reliance on blood transfusions in surgical settings.
Minimizing transfusion needs is crucial for patient safety and resource management.

Purpose of the Study:

To evaluate the efficacy of specific drugs in reducing perioperative blood transfusion requirements.
To identify patient populations and surgical contexts where drug interventions are most beneficial.
To compare the effectiveness of tranexamic acid, desmopressin, and recombinant factor VIIa.

Main Methods:

Review of existing literature on drug interventions for reducing surgical transfusions.
Analysis of studies focusing on tranexamic acid in hip/knee arthroplasty and cardiac surgery.
Assessment of desmopressin's utility in patients with normal preoperative hemostasis.
Evaluation of recombinant factor VIIa's role in managing massive hemorrhage and uncontrolled bleeding.

Main Results:

Tranexamic acid demonstrated a reduction in transfusion needs in total hip/knee arthroplasty and cardiac surgery.
Desmopressin did not show a significant benefit in reducing transfusions for patients with normal preoperative hemostasis.
Recombinant factor VIIa is considered for massive hemorrhage in trauma, postpartum, and cardiac surgery, and general surgical bleeding.

Conclusions:

Tranexamic acid is an effective drug for reducing transfusions in specific orthopedic and cardiac surgeries.
Desmopressin is not recommended for reducing transfusions in patients without preoperative hemostatic abnormalities.
Recombinant factor VIIa serves as a potential treatment for severe bleeding scenarios across various surgical and trauma contexts.