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Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

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Updated: Jul 6, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

[Iatrogeny and the elderly].

G Ungureanu¹, Ioana Dana Alexa, Ortansa Stoica

¹Clinica IV Medicală-Nefrologie, Facultatea de Medicină, Universitatea de Medicină si Farmacie "Gr.T. Popa", Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi

|April 9, 2008

Summary

This summary is machine-generated.

Iatrogeny, or harm from medical treatment, is a growing concern, especially for the elderly. Addressing this significant health issue is crucial for improving patient quality of life and reducing healthcare costs.

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Last Updated: Jul 6, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

Area of Science:

Gerontology
Medical Ethics
Public Health

Context:

Historically neglected, iatrogeny (harm caused by medical treatment) is gaining attention due to research on therapeutic compliance and patient education.
The aging global population and increased prevalence of iatrogenic conditions with age exacerbate its impact.
Iatrogenic pathology in the elderly is a significant, yet often overlooked, public health challenge.

Purpose:

To highlight the increasing impact of iatrogeny on general health, particularly in the elderly population.
To emphasize the need for a systematic approach to managing iatrogenic pathology.
To underscore the consequences of iatrogeny on patient longevity, quality of life, and healthcare expenditures.

Summary:

Iatrogeny, or harm arising from medical interventions, has been historically under-discussed but is now recognized as a critical issue.
The elderly demographic faces a disproportionately higher burden of iatrogenic conditions due to population aging and age-related disease prevalence.
This growing problem significantly affects patient outcomes and healthcare system costs, necessitating urgent attention and systematic management strategies.

Impact:

Increased awareness and systematic management of iatrogenic conditions can improve patient longevity and quality of life.
Addressing iatrogenic pathology can lead to more efficient allocation of healthcare resources and reduced medical costs.
Prioritizing research and interventions for iatrogenic harm, especially in vulnerable elderly populations, is essential for advancing patient care and public health.