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Updated: Jul 6, 2026
10:51
Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
Published on: April 23, 2021
[Android obesity and breast cancer risk]
Cynthia Petrovanu1, Adorata Elena Coman, G C Murariu
1Disciplina de Medicină de Ambulator, Facultatea de Medicină, Universitatea de Medicină Si Farmacie "Gr.T. Popa", Iaşi.
Summary
Android obesity, characterized by a high waist-to-hip ratio (WHR > 0.8), is significantly associated with increased serum estradiol levels in breast cancer patients. This finding suggests a link between abdominal obesity and breast cancer promotion.
Area of Science:
- Endocrinology
- Oncology
- Epidemiology
Background:
- Overweight (Body Mass Index > 25) is linked to increased incidence of several cancers, including breast cancer.
- Previous research indicated an inverse relationship between Body Mass Index and perimenopausal breast cancer.
Purpose of the Study:
- To investigate the association between obesity, specifically abdominal obesity, and breast cancer.
- To explore the relationship between body fat distribution, serum estradiol levels, and breast cancer risk.
Main Methods:
- A study involving 110 patients divided into three groups: newly diagnosed breast cancer, breast dysplasia, and a control group.
- Measurements included height, weight, abdominal and hip perimeters, lipidogram, and serum estradiol levels.
Main Results:
- 50% of breast cancer patients were obese (WHR > 0.8), compared to 46% in the breast dysplasia group and 66% in the control group.
- While overall obesity prevalence differences were not significant, a highly significant association was found between abdominal obesity and increased serum estradiol in the breast cancer group (p < 0.01).
Conclusions:
- Android obesity and estrogens are linked to breast cancer promotion.
- Synergic or common pathways may connect abdominal obesity, elevated estrogen levels, and breast carcinogenesis.
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