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Formulation development and optimization of Ibuprofen tablets by direct compression method.

Rabia Bushra¹, Muhammad Harris Shoaib, Nousheen Aslam

¹Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi-7520, Pakistan.

Pakistan Journal of Pharmaceutical Sciences

|April 9, 2008

Summary

This study optimized ibuprofen (200mg) tablet manufacturing using direct compression. Formulation F-6 demonstrated superior dissolution and assay, confirming direct compression as an effective, cost-efficient pharmaceutical production method.

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Area of Science:

Pharmaceutical Technology
Drug Manufacturing
Formulation Science

Background:

Ibuprofen is a widely used analgesic and anti-inflammatory drug.
Direct compression offers a cost-effective and simple manufacturing method for pharmaceuticals.
This technique is suitable for hygroscopic and thermolabile substances.

Purpose of the Study:

To prepare optimized 200mg Ibuprofen tablets using direct compression.
To evaluate the impact of diluent, disintegrant, and lubricant variations on tablet quality.
To identify the best formulation based on critical quality attributes.

Main Methods:

Nine different Ibuprofen tablet formulations were developed using direct compression.
Independent variables included diluent (X1), disintegrant (X2), and lubricant (X3).
Response variables assessed were weight variation, thickness, dimensions, hardness, friability, disintegration, dissolution, and pharmaceutical assay.

Main Results:

All nine formulations met official compendial standards.
Formulation F-6 was selected as optimal due to high dissolution (99.05%) and assay (100.04%).
F-6 exhibited minimal weight variation, indicating an optimal excipient ratio.

Conclusions:

Direct compression is an effective and efficient method for manufacturing Ibuprofen tablets.
Formulation optimization is a crucial tool in pharmaceutical product development.
The optimized Ibuprofen tablets (F-6) meet quality standards for patient use.