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Updated: Jul 6, 2026

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
Published on: January 7, 2020
Impact of music on pediatric oncology outpatients
Kathi J Kemper1, Craig A Hamilton, Thomas W McLean
1Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. kkemper@wfubmc.edu
Insights
Music listening improved relaxation in pediatric oncology outpatients. However, music did not significantly impact other well-being measures or heart rate variability (HRV) parameters, suggesting further research is needed.
Area of Science:
- Pediatric Oncology
- Music Therapy
- Psychoneuroimmunology
Background:
- Music is recognized for its potential to enhance psychological well-being.
- The specific effects of music interventions on pediatric oncology outpatients require further investigation.
Purpose of the Study:
- To evaluate the impact of music on the well-being of pediatric oncology outpatients undergoing maintenance or consolidation treatment.
- To assess music's effect on subjective measures (relaxation, well-being, vitality, anxiety, stress, depression) and objective measures (heart rate variability).
Main Methods:
- A within-subjects design was used, with patients serving as their own controls across two visits.
- At one visit, children rested for 20 minutes; at the other, they listened to music for 20 minutes.
- Subjective well-being was assessed using visual analog scales (VAS) completed by parents, and objective physiological data (heart rate variability) was collected.
Main Results:
- Relaxation scores significantly improved with music compared to rest (p < 0.01).
- A significant decrease was observed in the parasympathetic parameter of heart rate variability (HRV) during music listening compared to rest.
- No other significant differences were found in subjective or objective measures between the music and rest conditions.
Conclusions:
- Music listening demonstrated a positive effect on improving relaxation in pediatric oncology outpatients.
- The observed decrease in parasympathetic HRV warrants further investigation.
- Additional research is necessary to clarify the relationship between subjective and objective well-being indicators in this patient population, especially those not experiencing severe distress.
Abstract:
Music is widely used to enhance well-being. We wished to assess music's effect on pediatric oncology outpatients. Patients who had leukemia and were in maintenance or consolidation outpatient treatment served as their own control at two visits. At visit 1, children rested for 20 min; at visit 2, for 20 min they listened to music designed to increase vitality and improve heart rate variability (HRV). At both visits, parents completed before and after treatment visual analog scales (VAS) of their child's relaxation, well-being, vitality, anxiety, stress, and depression; patients' heart rates were monitored during treatments to calculate HRV. The 47 patients with complete VAS data and 34 patients with usable HRV data were similar. At baseline, VAS scores for negative states were low (average <2.5 of 10) and positive states were high (average 7> of 10). Relaxation improved more with music than rest (p < 0.01). The HRV parasympathetic parameter was significantly lower with music than rest. No other differences were significant. Further studies are needed to better delineate the relationship between subjective and objective measures of well-being among patients who are not in severe distress.
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