Related Experiment Video
Updated: May 9, 2026

Derivation of Leptomeninges Explant Cultures from Postmortem Human Brain Donors
Published on: January 21, 2017
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
Jeffrey H Kordower1, Yaping Chu, Robert A Hauser
1Department of Neurological Sciences and Center for Brain Repair, Rush University Medical Center, 1735 West Harrison Street, Chicago, Illinois 60612, USA. jkordowe@rush.edu
Abstract:
Fourteen years after transplantation into the striatum of an individual with Parkinson's disease, grafted nigral neurons were found to have Lewy body-like inclusions that stained positively for alpha-synuclein and ubiquitin and to have reduced immunostaining for dopamine transporter. These pathological changes suggest that Parkinson's disease is an ongoing process that can affect grafted cells in the striatum in a manner similar to host dopamine neurons in the substantia nigra. These findings have implications for cell-based therapies and for understanding the cause of Parkinson's disease.
Related Concept Videos
Neural Regulation
Lysosomal Hydrolases
Parkinson's Disease: Overview
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease l: Introduction
Parkinson Disease ll: Pathophysiology

