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The bone scan in disseminated BCGitis

Mehrossadat Alavi1, Shahideh Safavi

  • 1Department of Nuclear Medicine, Namazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Alavimh@sums.ac.ir

Hellenic Journal of Nuclear Medicine
|April 9, 2008
PubMed

Insights

Disseminated BCGitis, a rare but severe adverse reaction to the bacillus Calmette-Guerin (BCG) vaccine, can be diagnosed using bone (99m)Tc-MDP imaging. This imaging technique shows promise in identifying disseminated BCG infection in infants.

Area of Science:

  • Pediatric Infectious Diseases
  • Diagnostic Imaging
  • Vaccine Adverse Events

Background:

  • The bacillus Calmette-Guerin (BCG) vaccine is widely used globally, but rare adverse reactions can occur.
  • Disseminated BCGitis is a severe, potentially fatal complication, often linked to underlying immunodeficiency in infants.
  • Current diagnostic methods for disseminated BCGitis include PCR, CT, ultrasound, X-rays, and bone marrow aspiration.

Observation:

  • A case report details a 6-month-old female infant diagnosed with disseminated BCGitis.
  • The infant presented with symptoms indicative of disseminated BCG infection.

Findings:

  • Bone scintigraphy using technetium-99m methylene diphosphonate ((99m)Tc-MDP) revealed characteristic findings supporting the diagnosis.
  • The imaging findings were crucial in confirming disseminated BCGitis in this infant.

Implications:

  • Bone (99m)Tc-MDP imaging offers a valuable non-invasive tool for diagnosing disseminated BCGitis.
  • This imaging modality can aid in the early and accurate detection of disseminated BCG infection, potentially improving patient outcomes.
  • Further research into the utility of (99m)Tc-MDP imaging in managing BCG vaccine complications is warranted.

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