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Male age influences oocyte-donor program results
Eliezer Girsh1, Nathan Katz, Leonid Genkin
1Fertility Center, Assuta Medical Center, Rishon LeZion 57653, Israel. eligirsh@yahoo.com
Journal of Assisted Reproduction and Genetics
|April 9, 2008
Summary
Male age significantly impacts sperm parameters and in-vitro fertilization (IVF) success rates. Advanced paternal age is linked to reduced sperm quality and lower pregnancy rates, even in egg donation cycles.
Area of Science:
- Reproductive Medicine
- Andrology
- Infertility Research
Background:
- Male aging is a factor in reproductive outcomes.
- Egg Donation Programs (EDP) offer high-quality oocytes for sperm efficacy analysis.
- Understanding male age's impact on semen quality is crucial for fertility treatments.
Purpose of the Study:
- To investigate the relationship between male age and semen parameters.
- To analyze how male age affects sperm efficacy in Egg Donation Program (EDP) cycles.
- To determine if age-related decline in sperm parameters impacts in-vitro fertilization (IVF) success.
Main Methods:
- Retrospective analysis of 484 male partners in EDP-IVF cycles.
- Comparison of semen parameters between pregnant and non-pregnant groups.
- Evaluation of sperm morphology, strict criteria, and embryo quality in relation to male age.
Main Results:
- Men in the pregnant group were significantly younger (43.2 years) than in the non-pregnant group (46.8 years).
- Teratozoospermia was more prevalent in the non-pregnant group (29% vs. 11%).
- Semen parameters declined notably between ages 40-50, affecting sperm morphology and strict criteria.
Conclusions:
- Sperm parameters significantly decrease with advancing male age.
- Age-related decline in sperm quality may contribute to IVF cycle failures.
- Paternal age is a critical factor to consider in fertility evaluations and treatments.
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