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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: Jul 6, 2026

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
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Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

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[Benign odontogenic ectomesenchymal tumors].

G Jundt1, P A Reichart

  • 1Institut für Pathologie, DÖSAK-Zentralregister am Knochentumor-Referenzzentrum, Universitätsspital Basel, Schweiz. gernot.jundt@unibas.ch

Der Pathologe
|April 9, 2008
PubMed
Summary

Odontogenic ectomesenchymal tumors include fibromas, myxomas, and cementoblastomas. Complete resection is crucial for aggressive odontogenic myxomas to prevent recurrence and spread.

Area of Science:

  • Oral Pathology
  • Odontogenic Tumors
  • Ectomesenchymal Neoplasms

Context:

  • Odontogenic ectomesenchymal tumors encompass odontogenic fibroma, myxoma, and cementoblastoma.
  • Odontogenic myxoma is the fourth most common odontogenic tumor.
  • Diagnosis can be challenging due to similarities with normal dental structures and radiographic findings.

Purpose:

  • To differentiate between odontogenic fibroma, myxoma, and cementoblastoma.
  • To highlight diagnostic challenges and key histological features.
  • To recommend appropriate treatment strategies based on tumor behavior and location.

Summary:

  • Cementoblastoma diagnosis relies on its root connection. Differentiating fibromas and myxomas requires recognizing radiographic signs and histological clues like residual epithelium and dentin.

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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

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  • Odontogenic fibromas rarely recur after simple excision.
  • Cementoblastomas and particularly odontogenic myxomas exhibit high recurrence rates with intralesional procedures.

    • Impact:

    • Accurate diagnosis and histological assessment are vital for effective management.
    • Complete resection with clear margins is recommended for aggressive lesions, especially large odontogenic myxomas or those in the maxilla.
    • Preventing recurrence and further extension to critical structures like the orbit or skull base is paramount.