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Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
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Glucose in the dialysate: historical perspective and possible implications?
Rajiv Sharma1, Mitchell H Rosner
1Division of Nephrology, University of Virginia Health System, Charlottesville, Virginia 22903, USA.
Hemodialysis International. International Symposium on Home Hemodialysis
|April 9, 2008
Summary
High glucose in hemodialysis fluid may worsen inflammation. This review questions the routine use of glucose in dialysis, exploring its potential pro-inflammatory effects in end-stage renal disease patients.
Area of Science:
- Nephrology
- Biochemistry
- Inflammation Research
Background:
- Hemodialysate solutions commonly contain high glucose concentrations (up to 200 mg/dL).
- Historically, glucose was added to aid ultrafiltration and reduce caloric loss during dialysis.
Observation:
- Recent evidence suggests high glucose levels may promote inflammation.
- End-stage renal disease (ESRD) is linked to significant morbidity, mortality, and chronic inflammation.
Findings:
- This review examines the role of glucose in hemodialysate.
- It explores the potential pro-inflammatory implications of dialysate glucose in ESRD patients.
Implications:
- The routine use of glucose in dialysis fluid warrants reevaluation.
- Further research is needed to determine if dialysate glucose concentration causally impacts chronic inflammation in ESRD.
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