Related Experiment Video
Updated: Jul 6, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
Does lower response to alcohol explain the high co-morbidity between bipolar disorder and alcohol dependence?
1INSERM U675, IFR02, Faculté de Médecine Xavier Bichat/Université Paris 7, 16 Rue Henri Huchard, 75018 Paris, France.
Abstract:
The frequency of the co-occurrence between alcohol use disorders and bipolar disorder is well documented. However, the etiology of this association is discussed. Among the most quoted hypothesis, high alcohol consumption has been considered as a form of self-medication. At variance with this assumption, we hypothesized that mania is associated with a low level of response to alcohol. Indeed, a low level of response to alcohol was previously associated with an increased risk of alcohol dependence in a high risk population. We discuss the neurobiological findings supporting our assumption, including the decreased reward-related brain activation in mania and further propose a brief study design to test this hypothesis.
Related Concept Videos
CNS Depressants: Alcohol and Nicotine
Physical Properties of Alcohols and Phenols
Alcohols possess a higher boiling point than aliphatic hydrocarbons of similar...
Acidity and Basicity of Alcohols and Phenols
Bipolar Disorder
Alcohols from Carbonyl Compounds: Reduction
Catalytic hydrogenation is similar to the reduction of an alkene or alkyne by adding H2 across the pi bond in the presence of transition metal catalysts like Raney Ni, Pd–C, Pt, or Ru. Aldehydes and ketones can be reduced by this method, often under mild to moderate heat (25–100°C) and...
Depressants
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...

