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[Fractionation of a chalone-containing substance from Ehrlich's ascites tumor using high pressure chromatography]
Biulleten' Eksperimental'Noi Biologii I Meditsiny
|October 1, 1991
Abstract:
The effect of various fractions of chalone--containing preparation from ascyte Ehrlich's tumour obtained by high performance liquid chromatography (HPLC) on mitotic activity and DNA synthesis in the tumour has been studied. After filtration the division of active chalone component which inhibits entering cells into M-phase and S-phase took place. The component inhibiting DNA synthesis eluated with G1-chalone.