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Rapid Colorimetric Assays to Qualitatively Distinguish RNA and DNA in Biomolecular Samples
Published on: February 4, 2013
A novel pyrene-guanidiniocarbonyl-pyrrole cation efficiently differentiates between ds-DNA and ds-RNA by two
Laura Hernandez-Folgado1, Carsten Schmuck, Sanja Tomić
1Institut für Organische Chemie, Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.
Bioorganic & Medicinal Chemistry Letters
|April 9, 2008
Abstract:
At micromolar concentrations and equimolar conditions in respect to basepairs, a novel pyrene-guanidiniocarbonyl-pyrrole cation 1 exhibited a strong ICD signal at about lambda=300nm specifically upon the interaction with ds-DNA, while under the same conditions a new fluorescence maximum at lambda=480nm appeared exclusively upon the addition of ds-RNA.
