Related Experiment Video
Updated: Jul 6, 2026
08:23
Modified Technique for the Use of Neonatal Murine Hearts in the Langendorff Preparation
Published on: March 4, 2022
Routine continuous perfusion for aortic arch reconstruction in the neonate
Sunil P Malhotra1, Frank L Hanley
1Division of Pediatric Cardiac Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Summary
Continuous perfusion offers a promising alternative to deep hypothermic circulatory arrest for neonatal aortic arch reconstruction. This study details a standardized technique based on extensive clinical experience.
Area of Science:
- Cardiovascular Surgery
- Neonatal Medicine
- Pediatric Cardiac Surgery
Background:
- Continuous perfusion has emerged as a key cerebral protection strategy in neonatal aortic arch reconstruction over the last 15 years.
- It serves as a viable alternative to traditional deep hypothermic circulatory arrest (DHCA).
- A lack of standardized techniques for continuous perfusion application exists due to its recent development.
Purpose of the Study:
- To present a standardized approach for continuous perfusion during neonatal aortic arch repair.
- To share insights from extensive clinical experience with this technique.
Main Methods:
- Description of a specific continuous perfusion technique for aortic arch repairs.
- Experience derived from over 700 cases.
Main Results:
- The study is based on a large cohort of over 700 cases.
- The described approach has been refined through extensive clinical application.
Conclusions:
- The presented technique offers a standardized method for continuous perfusion in neonatal aortic arch reconstruction.
- This approach aims to optimize cerebral protection during these complex neonatal cardiac surgeries.
