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Updated: Jul 6, 2026

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices
Published on: February 5, 2015
Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF
Clas Malmeström1, Jan Lycke, Sara Haghighi
1Sahlgrenska Academy, Department of Neurology, Sahlgrenska University Hospital, Göteborg University, Göteborg, Sweden.
Abstract:
MS is thought to be mediated by CD4(+) T-helper cells. To investigate the importance of CD8(+) cytotoxic T-cells in MS we analyzed peripheral blood T-cells by DNA microarray, and plasma and CSF levels of granzymes from MS patients and controls. Cytotoxic gene expression was decreased in peripheral T-cells from RRMS patients whereas plasma levels of granzymes were unchanged. However, granzyme levels were elevated in the CSF of RRMS patients at relapse compared with controls and remission. Thus, CD8+ T-cell-mediated cytotoxicity is confined to the CSF/CNS compartment in RRMS patients and may be involved in the immunopathogenesis of clinical relapses.
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