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Related Experiment Video

Updated: Jul 6, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

[Constructing a small-diameter decellularized vascular graft pre-loaded with bFGF].

Min Zhou1, Changjian Liu, Zhiqin Wei

  • 1Department of Vascular Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing Jiangsu, 210008, P. R. China.

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery
|April 10, 2008
PubMed
Summary

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This study developed a novel decellularized vascular scaffold pre-loaded with basic fibroblast growth factor (bFGF) for small-caliber vascular grafts. The bFGF-loaded grafts demonstrated significantly improved patency and biocompatibility in canine carotid artery implantation compared to unloaded grafts.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Vascular Surgery

Context:

  • Small-caliber vascular grafts are crucial for treating vascular diseases.
  • Current synthetic grafts face challenges with patency and biocompatibility.
  • Decellularized allogeneic scaffolds offer a promising biomimetic alternative.

Purpose:

  • To design and evaluate a novel decellularized allogeneic vascular scaffold pre-loaded with basic fibroblast growth factor (bFGF).
  • To assess the efficacy of bFGF loading on scaffold biocompatibility and in vitro cell proliferation.
  • To determine the in vivo patency and histological outcomes of bFGF-loaded grafts in a canine carotid artery model.

Summary:

  • Detergent-enzymatic decellularization preserved extracellular matrix structure in canine carotid artery scaffolds.

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Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

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Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
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Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

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Related Experiment Videos

Last Updated: Jul 6, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method
09:38

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

Published on: March 27, 2017

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
09:23

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

Published on: June 16, 2015

  • Heparin conjugation enabled sustained release of covalently bound bFGF for up to 20 days.
  • bFGF-preloaded scaffolds significantly enhanced bone marrow-derived mesenchymal stem cell (BMSC) proliferation in vitro.
  • In vivo implantation showed an 87.5% patency rate for bFGF-loaded grafts versus 12.5% for unloaded grafts after 8 weeks.

    • Impact:

    • This study presents a novel strategy for developing small-diameter vascular grafts with enhanced biocompatibility and high patency rates.
    • The findings suggest that pre-loading decellularized scaffolds with bFGF can significantly improve graft performance and reduce occlusion.
    • This approach holds potential for advancing regenerative medicine in vascular reconstruction.