Related Experiment Video

Updated: Jul 6, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
09:14

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

Epstein-Barr virus related lymphoma in inflammatory bowel disease

S Van Biervliet1, S Vande Velde, R De Bruyne

  • 1Paediatric gastroenterology Unit, University Hospital Ghent, Ghent, Belgium. stephanie.vanbiervliet@ugent.be

Acta Gastro-Enterologica Belgica
|April 10, 2008
PubMed

Insights

Epstein-Barr virus (EBV) lymphoproliferative disease is a risk for children with inflammatory bowel disease (IBD) on immunosuppressants. Close monitoring of EBV status is crucial for these young patients.

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Hematology Oncology

Background:

  • Epstein-Barr virus (EBV) lymphoproliferative disease is a known risk in immunocompromised children, particularly post-transplant.
  • The rising incidence of pediatric inflammatory bowel disease (IBD) leads to increased use of immunomodulatory agents in EBV-naive children.
  • The risk of EBV-related lymphoproliferative disease in young IBD patients treated with immunosuppressants is not well-defined.

Observation:

  • A young patient with Crohn's disease (CD) developed an EBV-related lymphoma.
  • The lymphoma occurred shortly after EBV primo-infection.
  • The patient was undergoing treatment with azathioprine, an immunosuppressive drug.

Findings:

  • This case highlights a potential risk of EBV-induced lymphoproliferative disease in young IBD patients on immunosuppressive therapy.
  • The development of lymphoma suggests that EBV primo-infection can trigger significant complications in this population.

Implications:

  • Young IBD patients treated with immunosuppressive drugs require rigorous monitoring for EBV status.
  • Early detection and management of EBV complications are essential in this vulnerable pediatric population.
  • Further research is needed to compare the risk and evolution of EBV-related lymphoproliferative disease in IBD patients versus transplanted patients.

More Related Videos

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...