Allergy testing and referral in children

Marnie Robinson1, Joanne Smart

  • 1Immunology and Allergy Fellow, Royal Children's Hospital, Melbourne, Victoria. marnie.robinson@rch.org.au

Insights

Accurate diagnosis of childhood allergic diseases is crucial. Specialist paediatric allergists use tests like skin prick testing and RAST to confirm IgE-mediated allergies.

Area of Science:

  • Pediatric Allergy and Immunology
  • Clinical Immunology

Background:

  • Allergic diseases are prevalent chronic childhood conditions.
  • General practitioners frequently manage pediatric allergic diseases.
  • Understanding referral criteria and diagnostic tests is essential.

Purpose of the Study:

  • To outline criteria for referring children to a paediatric allergist.
  • To detail diagnostic tests used by allergists.

Main Methods:

  • Review of diagnostic criteria for paediatric allergic diseases.
  • Description of common allergy diagnostic tests.

Main Results:

  • Accurate diagnosis and allergen avoidance are key for managing allergic diseases.
  • Diagnosis of IgE-mediated allergy requires symptom history and specific IgE detection.
  • Common tests include skin prick testing, RAST, and oral food challenges.

Conclusions:

  • Specialist referral is indicated for complex pediatric allergy cases.
  • Reliable diagnostic methods are essential for effective management.
  • Unorthodox tests may yield misleading results and should be avoided.
Abstract

Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...