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Effects of natriuretic peptides on the centrally mediated pressor response to clonidine in freely moving rats
S Nakamura1, H Kawasaki, K Takasaki
1Department of Pharmacology, Miyazaki Medical College, Japan.
Japanese Journal of Pharmacology
|November 1, 1991
Abstract:
Effects of intracerebroventricular (i.c.v.) treatment with atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) on the pressor response to i.c.v.-injected clonidine were investigated in conscious rats. I.c.v.-pretreatment with ANP (10 micrograms) or BNP (10 micrograms) inhibited the pressor response to i.c.v.-injected clonidine (10 micrograms). Systemic (i.v.) treatment with ANP and BNP had no such effect. These results suggest that natriuretic peptides in the brain modulate the centrally mediated pressor response to clonidine.