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Related Concept Videos

Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Chronic Kidney Disease III: Interprofessional Care01:28

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...

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Related Experiment Video

Updated: Jul 6, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Proteomics and kidney stone disease.

Visith Thongboonkerd1

  • 1Medical Proteomics Unit & Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Contributions to Nephrology
|April 11, 2008
PubMed
Summary
This summary is machine-generated.

Kidney stone disease (nephrolithiasis) remains poorly understood, hindering effective prevention. Proteomics offers a promising high-throughput tool to investigate stone formation mechanisms and identify new therapeutic targets.

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Published on: March 4, 2022

Area of Science:

  • Nephrology
  • Biochemistry
  • Proteomics

Background:

  • Kidney stone disease (nephrolithiasis) is a prevalent, ancient condition with a long history.
  • Despite its prevalence, the precise pathogenic and molecular mechanisms underlying kidney stone formation are not well understood.
  • Current prevention strategies are often ineffective, highlighting the need for further research.

Purpose of the Study:

  • To elucidate the poorly understood pathogenic and molecular mechanisms of kidney stone formation.
  • To identify novel therapeutic targets for improved treatment and prevention of kidney stone occurrence and recurrence.
  • To provide an overview of proteomic methodologies and recent studies applied to nephrolithiasis research.

Main Methods:

  • Application of high-throughput proteomics techniques.
  • Investigation of proteomic methodologies used in nephrolithiasis research.
  • Summarization of recent proteomic studies focused on kidney stones.

Main Results:

  • Proteomics has emerged as a powerful tool in nephrology research over the past five years.
  • High-throughput proteomic capabilities show significant promise for advancing kidney stone research.
  • Recent proteomic studies have begun to shed light on nephrolithiasis.

Conclusions:

  • Further elucidation of kidney stone formation mechanisms is crucial.
  • Proteomics offers a promising avenue for identifying new therapeutic targets for kidney stones.
  • Continued application of proteomics is essential for improving the prevention and treatment of nephrolithiasis.