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Updated: Jul 6, 2026

Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes
Published on: June 25, 2017
Simulating the cellular passive transport of glucose using a time-dependent extension of Gillespie algorithm for
1Microsoft Research, University of Trento, Centre for Computational and System Biology, Italy. lecca@cosbi.eu
Abstract:
Realistic simulations of the biological systems evolution require a mathematical model of the stochasticity of the involved processes and a formalism for specifying the concurrent nature of the biochemical interactions. A time-dependent extension of the Gillespie algorithm implementing the race condition of the stochastic pi-calculus formalism satisfies both these requirements. This paper formulates those modifications to the original Gillespie algorithm necessary when the time dependence of the reaction propensity is due to changes either of volume or temperature. This re-formulation has been incorporated in the framework of stochastic pi-calculus and has been applied to simulate the passive glucose cellular transport.
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