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Detrusor Underactivity Model in Rats by Conus Medullaris Transection

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Published on: August 28, 2020

[Urinary dysfunction in idiopathic normal pressure hydrocephalus].

Ryuji Sakakibara¹, Tomoyuki Uchiyama, Takemasa Kanda

¹Neurology Division, Department of Internal Medicine, Sakura Medical Center, Toho University, Shimoshizu, Sakura, Chiba 285 8741, Japan.

Brain and Nerve = Shinkei Kenkyu No Shinpo

|April 12, 2008

Summary

This summary is machine-generated.

Urinary incontinence (UI) in elderly patients is often linked to normal pressure hydrocephalus (NPH). This condition commonly causes overactive bladder (OAB) and detrusor overactivity (DO) due to neurological factors.

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Area of Science:

Geriatrics
Neurology
Urology

Context:

Urinary incontinence (UI) presents a significant burden for elderly individuals and their caregivers, impacting quality of life, necessitating early institutionalization, and incurring substantial health economic costs.
UI is a key component of the diagnostic triad for normal pressure hydrocephalus (NPH).

Purpose:

To explore the relationship between urinary symptoms and normal pressure hydrocephalus (NPH).
To investigate the urodynamic findings and potential pathophysiology of lower urinary tract symptoms in NPH patients.

Summary:

Normal pressure hydrocephalus (NPH) patients frequently experience urinary urgency and frequency (overactive bladder: OAB), and sometimes voiding difficulties.
Detrusor overactivity (DO) is the most common urodynamic abnormality, present in 95% of NPH patients, with 14% exhibiting post-void residual urine exceeding 100 ml.
The pathophysiology of OAB/DO in NPH is associated with reduced cerebral blood flow in the right frontal cortex and altered basal ganglia function.
Functional UI can co-exist with OAB/DO in NPH due to cognitive impairment, immobility, or altered consciousness.

Impact:

Understanding the urinary dysfunction in NPH can lead to improved diagnostic accuracy and targeted therapeutic interventions.
This research highlights the neurological underpinnings of bladder dysfunction in NPH, potentially improving patient management and outcomes.