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Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
Published on: October 25, 2019
Leptin, a novel predictor of lung function in heart failure
Justo Sierra-Johnson1, Abel Romero-Corral2, Virend K Somers2
1Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Chest
|April 12, 2008
Summary
Serum leptin levels predict reduced lung function, including forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), in chronic heart failure patients. This finding is independent of body fat and ejection fraction.
Area of Science:
- Cardiology
- Pulmonology
- Endocrinology
Background:
- Leptin, a protein hormone from adipose tissue, exhibits proinflammatory properties.
- Leptin levels are typically elevated in individuals with chronic heart failure.
- The study investigates the association between serum leptin and lung function decline in noncachectic heart failure patients.
Purpose of the Study:
- To determine if serum leptin levels correlate with diminished lung function in patients with chronic heart failure.
- To assess the predictive value of leptin for lung function parameters in heart failure.
Main Methods:
- 135 stable systolic heart failure patients and 106 matched controls were prospectively recruited.
- Lung function was assessed using spirometry (FVC, FEV1) and single-breath carbon monoxide diffusing capacity (DLco).
- Plasma leptin was quantified via radioimmunoassay, and multiple linear regression analysis was employed.
Main Results:
- Leptin's relationship with lung function differed significantly between heart failure patients and controls after adjusting for covariates.
- In heart failure patients, leptin independently predicted FVC (R(2)=0.05, p<0.0001), FEV1 (R(2)=0.05, p<0.0001), and DLco (R(2)=0.14, p<0.0001).
- Leptin remained a significant independent predictor of lung function in heart failure even after further adjustments in a multiple regression model.
Conclusions:
- Leptin provides predictive information on lung function in heart failure patients, which is additive to body fat measures, particularly for DLco.
- Leptin may contribute to the observed impairment of lung function in individuals suffering from heart failure.
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